蒋百春
博士，副教授
E-mail: jiangbaichun@sdu.edu.cn
学习和工作经历：
2017.09-至今： 山东大学基础医学院遗传学系，副教授
2010.07-2017.08： 山东大学医学院遗传学系，讲师
2004.09-2010.06： 山东大学医学院医学遗传学专业，博士
2007.06-2008.05： Baylor College of Dentistry, Health Science Center, Texas A&M University，联合培养博士生
2006.06-2007.05： University of Missouri-Kansas City，联合培养博士生
2000.09-2004.06： 山东大学生命科学学院生物科学专业，学士
学术兼职：
山东省医学会医学遗传与优生学分会委员、《中华医学遗传学杂志》通讯编委。
教学工作：
承担临床医学五年制、5+3、口腔医学、预防医学等专业本科生《细胞、分子及遗传学》、《医学遗传学》等课程理论和实验教学，以及研究生《细胞遗传学》、《现代生物学方法》课程教学。承担多项校级及院级教研课题。
研究方向：
遗传病致病基因的功能研究。
主持课题：
1. 国家自然科学基金（面上项目），31970559，CUL4B在小鼠卵母细胞和早期胚胎发育过程中的作用及分子机制研究，2020.01-2023.12，课题负责人
2. 山东省重点研发计划，2016GSF201143，CUL4B做为分子标志物在结直肠癌早期分子诊断中的应用，2016.01-2018.12，课题负责人
3. 国家自然科学基金（青年基金），81101522，利用转基因小鼠模型研究CUL4B基因在肝细胞癌发生发展中的作用及机制，2012.01-2014.12，课题负责人
4. 山东省优秀中青年科学家科研奖励基金，BS2011YY031，利用基因敲除小鼠模型研究Cul4b基因在早期胚胎发育中的功能，2011.07-2014.07，课题负责人
5. 山东省博士后创新项目专项资金，201003065，Cul4b基因在小鼠胚胎发育中的作用机制研究，2010-2012，课题负责人
6. 山东大学自主创新基金人才引进与培养类专项，2010GN042，Cul4b基因在小鼠早期胚胎发育中的作用及其机制，2010.10-2012.12，课题负责人
发表论文：
1: Ma Y, Liu X, Zhou M, Sun W, Jiang B, Liu Q, Wang M, Zou Y, Liu Q, Gong Y, Sun G. CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. Cell Death Dis. 2024 Feb 8;15(2):121.
2: Liu X, Tian F, Cui J, Gong L, Xiang L, Fan B, Liu S, Zhan J, Zhou Y, Jiang B, Wang M, Sun G, Gong Y, Zou Y. CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells. Oncogene. 2023 Oct;42(42):3113-3126.
3: Wang R, Wang Y, Liu X, Liu M, Sun L, Pan X, Hu H, Jiang B, Zou Y, Liu Q, Gong Y, Wang M, Sun G. Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFκB signaling. Cell Death Dis. 2023 Jun 30;14(6):388.
4: Wang Y, Wang R, Liu X, Liu M, Sun L, Pan X, Hu H, Jiang B, Zou Y, Liu Q, Gong Y, Wang M, Sun G. Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12. Oncogenesis. 2023 Jun 24;12(1):34.
5: Yu R, Han H, Chu S, Ding Y, Jin S, Wang Y, Jiang W, Liu Y, Zou Y, Wang M, Liu Q, Sun G, Jiang B, Gong Y. CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ. Bone Res. 2023 Jun 2;11(1):29.
6: Jin S, Song Y, Zhou L, Jiang W, Qin L, Wang Y, Yu R, Liu Y, Diao Y, Zhang F, Liu K, Li P, Hu H, Jiang B, Tang W, Yi F, Gong Y, Liu G, Sun G. Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell Rep. 2023 Jun 27;42(6):112550.
7: Qin L, Song Y, Zhang F, Wang R, Zhou L, Jin S, Chen C, Li C, Wang M, Jiang B, Sun G, Ma C, Gong Y, Li P. CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation. Cell Death Differ. 2023 Jun;30(6):1488-1502.
8: Wang Y, Qin Q, Yang Y, Dong S, Liu Y, Wang M, Zou Y, Gong Y, Zhou H, Jiang B. A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility. J Assist Reprod Genet. 2023 Jan;40(1):75-81.
9: Song Y, Zan W, Qin L, Han S, Ye L, Wang M, Jiang B, Fang P, Liu Q, Shao C, Gong Y, Li P. Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation. Mol Metab. 2022 Feb;56:101423.
10: Kong Y, Wang L, Jiang B. The Role of Gut Microbiota in Aging and Aging Related Neurodegenerative Disorders: Insights from Drosophila Model. Life (Basel). 2021 Aug 20;11(8):855.
11: Shan H, Wang B, Zhang X, Song H, Li X, Zou Y, Jiang B, Hu H, Dou H, Shao C, Gao L, Ma C, Yang X, Liang X, Gong Y. CUL4B facilitates HBV replication by promoting HBx stabilization. Cancer Biol Med. 2021 May 9;19(1):120–31.
12: Wang Y, Pan X, Li Y, Wang R, Yang Y, Jiang B, Sun G, Shao C, Wang M, Gong Y. CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis. J Pathol. 2021 Jun;254(2):185-198.
13: Wang Z, Jiang B, Jin S, Hu Z, Liu G. Compound Mutations of the COL4A3 including a Novel Allele Identified in a Patient with Alport Syndrome. Biomed Res Int. 2020 Nov 11;2020:1626378.
14: Liu X, Cui J, Gong L, Tian F, Shen Y, Chen L, Wang Y, Xia Y, Liu L, Ye X, Wang M, Liu G, Jiang B, Shao C, Zou Y, Gong Y. The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer. Oncogene. 2020 Apr;39(17):3588-3603.
15: Li Y, Hu H, Wang Y, Fan Y, Yang Y, Guo B, Xie X, Lian J, Jiang B, Han B, Wang Y, Shao C, Gong Y. CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer. Oncogenesis. 2020 Feb 13;9(2):20.
16: Song Y, Li P, Qin L, Xu Z, Jiang B, Ma C, Shao C, Gong Y. CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription. Cell Mol Immunol. 2021 Feb;18(2):339-349.
17: Wang M, Xu Z, Liu Q, Sun W, Jiang B, Yang K, Li J, Gong Y, Liu Q, Liu D, Li X. Nongenetic optical modulation of neural stem cell proliferation and neuronal/glial differentiation. Biomaterials. 2019 Dec;225:119539.
18: Xu Z, Li L, Qian Y, Song Y, Qin L, Duan Y, Wang M, Li P, Jiang B, Ma C, Shao C, Gong Y. Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells. Oncogene. 2019 Jul;38(30):5860-5872.
19: Kong Y, Jiang B, Luo X. Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model. Future Microbiol. 2018 Aug;13:1117-1128.
20: Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. 2017 Jun 30;127(7):2631-2646.
21: Mi J, Zou Y, Lin X, Lu J, Liu X, Zhao H, Ye X, Hu H, Jiang B, Han B, Shao C, Gong Y. Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma. Mol Oncol. 2017 Mar;11(3):305-319.
22: Liu P, Jiang B, Ma J, Lin P, Zhang Y, Shao C, Sun W, Gong Y. S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model. Dis Model Mech. 2017 Jan 1;10(1):53-62.
23: Li P, Song Y, Zan W, Qin L, Han S, Jiang B, Dou H, Shao C, Gong Y. Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity. Diabetes. 2017 Feb;66(2):300-313.
24: Qian Y, Yuan J, Hu H, Yang Q, Li J, Zhang S, Jiang B, Shao C, Gong Y. The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. Cancer Res. 2015 Dec 1;75(23):5070-83.
25: Zhao W, Jiang B, Hu H, Zhang S, Lv S, Yuan J, Qian Y, Zou Y, Li X, Jiang H, Liu F, Shao C, Gong Y. Lack of CUL4B leads to increased abundance of GFAP- positive cells that is mediated by PTGDS in mouse brain. Hum Mol Genet. 2015 Aug 15;24(16):4686-97.
26: Yuan J, Jiang B, Zhang A, Qian Y, Tan H, Gao J, Shao C, Gong Y. Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. Oncotarget. 2015 Jun 20;6(17):15209-21.
27: Yuan J, Han B, Hu H, Qian Y, Liu Z, Wei Z, Liang X, Jiang B, Shao C, Gong Y. CUL4B activates Wnt/β-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. J Pathol. 2015 Apr;235(5):784-95.
28: Li J, Zhao X, Xin Q, Shan S, Jiang B, Jin Y, Yuan H, Dai P, Xiao R, Zhang Q, Xiao J, Shao C, Gong Y, Liu Q. Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing loss DFNB99. Hum Mutat. 2015 Jan;36(1):98-105.
29: Zhao X, Jiang B, Hu H, Mao F, Mi J, Li Z, Liu Q, Shao C, Gong Y. Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Hum Mol Genet. 2015 Feb 1;24(3):853-64.
30: Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L, Qian Y, Jiang B, Zou Y, Wang Y, Shao C, Gong Y. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 2014 Nov 1;127(Pt 21):4679-91.
31: Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z, Hu H, Yang Y, Gao X, Jiang B, Shao C, Gong Y. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol. 2013 Mar 18;200(6):743-56.
32: He F, Lu D, Jiang B, Wang Y, Liu Q, Liu Q, Shao C, Li X, Gong Y. X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochim Biophys Acta. 2013 May;1832(5):595-605.
33: Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, Yuan J, Liu Q, Li X, Zou Y, Shao C, Shang Y, Wang Y, Gong Y. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012 Dec 11;22(6):781-95.
34: Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, Guo C, Chen B, Shao C, Gong Y. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One. 2012;7(5):e37070.
35: Cao Z, Jiang B, Xie Y, Liu CJ, Feng JQ. GEP, a local growth factor, is critical for odontogenesis and amelogenesis. Int J Biol Sci. 2010 Nov 25;6(7):719-29.
36: Jiang B, Cao Z, Lu Y, Janik C, Lauziere S, Xie Y, Poliard A, Qin C, Ward LM, Feng JQ. DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. J Bone Miner Res. 2010 Oct;25(10):2155-64.
37: Li J, Yang Y, Jiang B, Zhang X, Zou Y, Gong Y. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. BMC Genet. 2010 Feb 8;11:12.
38: Feng JQ, Guo FJ, Jiang BC, Zhang Y, Frenkel S, Wang DW, Tang W, Xie Y, Liu CJ. Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis. FASEB J. 2010 Jun;24(6):1879-92.
39: Lu X, Rios HF, Jiang B, Xing L, Kadlcek R, Greenfield EM, Luo G, Feng JQ. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots. Eur J Oral Sci. 2009 Dec;117(6):625-35.
40: Feng JQ, Scott G, Guo D, Jiang B, Harris M, Ward T, Ray M, Bonewald LF, Harris SE, Mishina Y. Generation of a conditional null allele for Dmp1 in mouse. Genesis. 2008 Feb;46(2):87-91.
41: Xia Y, Jiang B, Zou Y, Gao G, Shang L, Chen B, Liu Q, Gong Y. Sp1 and CREB regulate basal transcription of the human SNF2L gene. Biochem Biophys Res Commun. 2008 Apr 4;368(2):438-44.
获奖情况：
1. 教育部2018年度高等学校科学研究优秀成果奖（科学技术）自然科学二等奖，CUL4B基因突变及表达失调在疾病发生中的作用及其机制研究（第四位）
2. 2011年度山东大学优秀博士学位论文
3. 2008年在加拿大蒙特利尔市召开的美国骨骼和矿化研究学会（American Society for Bone and Mineral Research, ASBMR）第30届年会颁发的青年学者奖（Young Investigator Award）
4. 2008年由国际华人骨研学会（International Chinese Hard Tissue Society, ICHTS）颁发的青年学者奖（Webster Jee Young Investigation Award）
